Protection of Hydroxyl Groups as a Trimethylsilyl Ether by 1,1,1,3,3,3-Hexamethyldisilazane Promoted by Aspartic Acid as an Efficient Organocatalyst

A wide variety of alcohols and phenols were protected as trimethylsilyl ethers using 1,1,1,3,3,3-hexamethyl disilazane catalyzed by aspartic acid as a non-toxic, metal-free, and green organocatalyst at room temperature in acetonitrile under mild and heterogeneous conditions. The procedure is operationally simple and the silylated product was obtained in high yield and purity.

Graphical abstractAn efficient catalytic procedure was developed for the trimethylsilylation of alcohols and phenols using 1,1,1,3,3,3-hexamethyldisilazane (HMDS) and aspartic acid as catalysts.Figure optionsDownload full-size imageDownload as PowerPoint slide