Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6031711 | NeuroImage | 2012 | 5 Pages |
Abstract
During the past 20Â years, BOLD fMRI has developed towards a central and fundamental tool in neuroscience. It has been shown that the BOLD response provides an indicator of neuronal activity in the brain. Consequently, for an accurate interpretation of findings in BOLD MRI experiments and to draw meaningful conclusions about the temporal evolution of neural events, a deep understanding of the nature of the BOLD contrast has become of essential importance. Since the dynamics of the major direct determinants of the BOLD signal (CBF, CBV and CMRO2) range between seconds and minutes, long duration stimulation was an early key strategy needed to study and understand the BOLD characteristics. This paper summarizes and discusses the thoughts and rationales of the long duration stimulation studies.
Keywords
Related Topics
Life Sciences
Neuroscience
Cognitive Neuroscience
Authors
Gunnar Krueger, Cristina Granziera,