| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6031722 | NeuroImage | 2012 | 14 Pages |
Abstract
⺠Drug-induced phMRI changes reflect receptor distributions, function and signaling. ⺠Selective pharmacologic challenges can open the black box of neurovascular coupling. ⺠Most drug stimuli produce positive and negative hemodynamic responses. ⺠Pharmacodynamics and pharmacokinetics can potentially be measured with phMRI. ⺠PhMRI is a molecular imaging tool with very high sensitivity rivaling PET.
Keywords
CBVCMRGlc7-NIphMRImRNAMPTPCBFCFTBOLD1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine7-nitroindazolel-NAMENω-nitro-l-arginine methyl esterFunctional MRIMRINeurotransmittersMagnetic resonance imagingfMRIcerebral blood flowCerebral blood volumeDrugsDopaminemessenger ribonucleic acidblood brain barrierBBBblood oxygenation level dependentNitric oxideHemodynamicsReceptor
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Authors
Bruce G. Jenkins,