| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6031852 | NeuroImage | 2012 | 7 Pages |
Abstract
⺠We evaluate if the 5-HTTLPR variant predicts serotonin 4 receptor (5-HT4) binding. ⺠We assess 5-HT4 binding with [11C]SB207145 PET in 47 healthy human volunteers. ⺠5-HTTLPR status significantly predicts neocortical [11C]SB207145 binding. ⺠S allele carriers show 9% reduced binding across neocortex versus LL homozygotes. ⺠This further suggests that 5-HTTLPR affects 5-HT neurotransmission in adult humans.
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![5-HTTLPR status predictive of neocortical 5-HT4 binding assessed with [11C]SB207145 PET in humans](/preview/png/6031852.png "First Page Preview: 5-HTTLPR status predictive of neocortical 5-HT4 binding assessed with [11C]SB207145 PET in humans")
Authors
Patrick M. Fisher, Klaus K. Holst, Brenda Mc Mahon, Mette E. Haahr, Karine Madsen, Nic Gillings, William F. Baaré, Peter S. Jensen, Gitte M. Knudsen,