Identifying improved TSPO PET imaging probes through biomathematics: The impact of multiple TSPO binding sites in vivo

► Biomathematics is used to predict the in vivo performance of TSPO PET tracers. ► Multiple binding affinities of the TSPO tracers are accounted for. ► Polymorphism frequencies in different ethnic groups are considered. ► 2nd generation TSPO tracers are predicted to be better than 11C-(R)-PK11195. ► Improvements are predicted for both within and between subject studies.