Magnetic resonance imaging of resting OEF and CMRO2 using a generalized calibration model for hypercapnia and hyperoxia

Application of this procedure in a group of seven human subjects provided average values of 0.35 ± 0.04 and 6.0 ± 0.7% for OEF0 and M, respectively in gray-matter (M valid for 30 ms echo-time at 3 T). Multiplying OEF0 estimates by the individual values of resting gray-matter CBF (mean 52 ± 5 ml/100 g/min) and the measured arterial O2 content gave a group average resting CMRO2 value of 145 ± 30 μmol/100 g/min. The method also allowed the generation of maps depicting resting OEF, BOLD signal, and CMRO2.