| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6032252 | NeuroImage | 2011 | 7 Pages |
Abstract
⺠[18F]altanserin PET investigates cognition induced changes at the 5-HT2a receptor. ⺠Binding potentials of working memory (WM) and a control task are compared voxelwise. ⺠WM induces an increased binding potential in orbitofrontal cortex, but no decreases. ⺠Results point to an orbitofrontally reduced serotonin release at the 5-HT2a receptor. ⺠This indicates optimization of the WM-related central executive via 5-HT2a receptors.
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![Cognition-induced modulation of serotonin in the orbitofrontal cortex: A controlled cross-over PET study of a delayed match-to-sample task using the 5-HT2a receptor antagonist [18F]altanserin](/preview/png/6032252.png "First Page Preview: Cognition-induced modulation of serotonin in the orbitofrontal cortex: A controlled cross-over PET study of a delayed match-to-sample task using the 5-HT2a receptor antagonist [18F]altanserin")
Authors
Hubertus Hautzel, Hans-Wilhelm Müller, Hans Herzog, Rüdiger Grandt,