Diffusion tensor imaging of white matter tract evolution over the lifespan

► We model diffusion changes across the lifespan (5-83 years) using tractography. ► Fractional anisotropy (FA) and mean diffusivity (MD) show non-linear trajectories. ► FA peaks occurred between 20-42 years and MD minima occurred between 18-43 years. ► The fornix and callosal tracts had the earliest trend reversals. ► The frontal-temporal connections had the most prolonged development.