| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6032655 | NeuroImage | 2012 | 9 Pages |
Abstract
⺠PET imaging of 5-HT1A receptor density in MDD patients has yielded mixed results. ⺠'Methodological' rather than 'clinical' factors likely explain these discrepancies. ⺠One methodological confound is the use of the cerebellum as a reference region. ⺠Measuring parent radioligand concentrations in arterial plasma is imprecise. ⺠Other confounds are efflux transporter, radiometabolites, & 5-HT1A affinity states.
Related Topics
Life Sciences
Neuroscience
Cognitive Neuroscience
Authors
Saurav Shrestha, Jussi Hirvonen, Christina S. Hines, Ioline D. Henter, Per Svenningsson, Victor W. Pike, Robert B. Innis,