Chemoselective and Catalytic Trimethylsilylation of Alcohols and Phenols by 1,1,1,3,3,3-Hexamethyldisilazane and Catalytic Amounts of PhMe3N+Br3−

An efficient procedure for the trimethylsilylation of alcohols and phenols is presented. The combination of 1,1,1,3,3,3-hexamethyldisilazane and a catalytic amount of phenyltrimethylammonium tribromide (PhMe3N+Br3−) was found to be effective for the trimethylsilylation of alcohols and phenols. The protection reaction is very simple and homogenously performed in dichloromethane at room temperature and mild conditions.

Graphical abstractAn efficient method for the trimethylsilylation of alcohols and phenols using 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amounts of phenyltrimethylammonium tribromide in CH2Cl2 at room temperature is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide