Multiple white matter tract abnormalities underlie cognitive impairment in RRMS

Article ID	Journal	Published Year	Pages	File Type
6032795	NeuroImage	2012	10 Pages	PDF

Abstract

âº Reductions in FA are seen throughout the brain, even within normal-appearing WM. âº Widespread association between reduced FA and cognitive impairment in MS. âº TBSS with TFCE allows better detection of WM abnormalities. âº SDMT shows strongest, widespread association to DTI-derived WM changes. âº FA changes due to increased radial diffusivity, an indirect measure of demyelination.

Keywords

Symbol Digit Modalities Test sRT RAVLT EDSS NAWM BPF EPI SDMT DTI PASAT CVLT RRMs axial diffusivity relapsing remitting multiple sclerosis California verbal learning test Rey Auditory Verbal Learning Test FLAIR MRI radial diffusivity fluid attenuated inversion recovery Paced Auditory Serial Addition Test echo planar imaging diffusion tensor imaging Magnetic resonance imaging CNS central nervous system Normal-appearing white matter mean diffusivity Expanded Disability Status Scale fractional anisotropy Brain parenchymal fraction