Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: Quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone

► We present the most comprehensive characterisation of 11C-MDL100907 to date. ► Test-retest reliability is good or very good in all neocortical regions. ► Maximum injected mass of tracer to remain below 5% receptor occupancy is 4.6 μg. ► The cerebellum is validated as a reference region. ► 11C-MDL100907 is not vulnerable to competition with reduced endogenous 5-HT.