| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6033126 | NeuroImage | 2012 | 11 Pages |
Abstract
⺠We examined progressive gray matter loss in first-episode schizophrenia with VBM. ⺠A novel feature was validation of DARTEL-based VBM analysis with manual ROI results. ⺠VBM revealed widespread and regionally concentrated progressive gray matter loss. ⺠Validation analyses showed similar results as our manual region of interest studies. ⺠Volume reductions showed rich associations with symptoms and cognitive dysfunction.
Keywords
FDRROIBPRSStgVBMMMSEsmall volume correctionSVCFirst-episode schizophreniahealthy control subjectsLongitudinal studydiffeomorphic anatomical registration through exponentiated Lie algebraDARTELsuperior temporal gyrusHeschl’s gyrusPositive symptomNegative symptomCognitive functionFirst episodeGray matterMini-Mental State ExaminationBrief Psychiatric Rating Scaleregion of interestvoxel-based morphometryfalse discovery rate
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Authors
Takeshi Asami, Sylvain Bouix, Thomas J. Whitford, Martha E. Shenton, Dean F. Salisbury, Robert W. McCarley,