| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6033401 | NeuroImage | 2016 | 10 Pages |
Abstract
⺠Microglia activation (MA) has both neurotoxic and prorepair effects after stroke. ⺠Does the regional distribution of 11C-PK11195 correlate with in vitro MA post stroke? ⺠In rats we found significant correlation between Day 14 11C-PK11195 and OX42 staining. ⺠Statistically significant 11C-PK11195 binding increases were also present at Day 2. ⺠These results further validate the use of 11C-PK11195 PET for MA imaging after stroke.
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![A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation](/preview/png/6033401.png "First Page Preview: A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation")
Authors
J.L. Hughes, P.S. Jones, J.S. Beech, D. Wang, D.K. Menon, F.I. Aigbirhio, T.D. Fryer, J.C. Baron,