| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6033869 | NeuroImage | 2011 | 8 Pages |
Abstract
âºIn this study, we used [11C]DAC with high SA (4060 GBq/μmol) to perform autoradiography and PET studies on the infarcted rat brains at day 2 after ischemia. âºThe early infarction in the brain could be visualized using PET with high SA [11C]DAC. âºIn vitro autoradiography showed that the TSPO expression increased on the infarcted area. âºHigh SA [11C]DAC is a useful biomarker for infarction by investigating the TSPO expression with small changes in the neuroinflammatory brain.
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![Visualization of early infarction in rat brain after ischemia using a translocator protein (18Â kDa) PET ligand [11C]DAC with ultra-high specific activity](/preview/png/6033869.png "First Page Preview: Visualization of early infarction in rat brain after ischemia using a translocator protein (18Â kDa) PET ligand [11C]DAC with ultra-high specific activity")
Authors
Joji Yui, Akiko Hatori, Kazunori Kawamura, Kazuhiko Yanamoto, Tomoteru Yamasaki, Masanao Ogawa, Yuichiro Yoshida, Katsushi Kumata, Masayuki Fujinaga, Nobuki Nengaki, Toshimitsu Fukumura, Kazutoshi Suzuki, Ming-Rong Zhang,