Effective connectivity anomalies in human amblyopia

► This is the first report of effective connectivity in amblyopia ► It is the first report of a reduction in effective connectivity that is unrelated to the fMRI loss. ► It is the first report showing a correlation between the effective connectivity deficit and the behavioural loss; this is not the case for the fMRI loss. ► It shows that both feedforward and feedback connectivities are reduced in amblyopia. ► It provides additional support for the LGN loss previously reported not being due solely to cortical feedback influences. ► It shows that effective connectivities are reduced for both the dorsal and ventral cortical pathways.