Article ID Journal Published Year Pages File Type
6034382 NeuroImage 2011 10 Pages PDF
Abstract
►Parkinson's disease tremor network is characterized by covarying metabolic increases in the cerebellum, motor cortex, and putamen. ►This network correlates specifically with clinical tremor ratings, but not with other motor manifestations of the disease. Its activity is elevated in tremor-dominant versus akinesia-dominant patients. ►The activity of this network progresses over time at a slower rate than the previously validated akinesia network. ►Relief of tremor symptoms by thalamic DBS selectively reduces the activity of this network. By contrast, STN DBS reduces abnormal activity of both tremor- and akinesia-related brain networks.
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