| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6034517 | NeuroImage | 2011 | 8 Pages |
Abstract
âºAmygdala hyperactivity may constitute a vulnerability factor for major depressive disorder, by playing a role in mnemonic processing of neutral information and not only emotional information âºAmygdala hyperactivity, which in MDD has been repeatedly shown in baseline or rest conditions, interferes with demanding mnemonic tasks that are not affectively laden. Successful episodic memory formation in depression depends on this amygdala contribution. âºDuring the acute state, depressed patients show an over-recruitment of a cortico-limbic network that is related to both episodic memory and mood. This may play a compensatory role early in the course of MDD and can be related to cognitive aspect of memory in depression.
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Authors
Philip van Eijndhoven, Guido van Wingen, Guillén Fernández, Mark Rijpkema, Robbert Jan Verkes, Jan Buitelaar, Indira Tendolkar,