Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest

Article ID	Journal	Published Year	Pages	File Type
6034551	NeuroImage	2011	12 Pages	PDF

Abstract

âº First use of probabilistic and template ROIs for Mawlawi sub-striatal regions. âº Probabilistic ROIs superior to template ROIs for binding potential quantification. âº ART spatial normalization produces superior results compared to SPM5. âº Probabilistic ROIs maintain statistical significance of results from manual ROIs. âº High quality probabilistic sub-striatal ROIs can be produced from â¥Â 9 subjects.

Keywords

VAS VST ASRS MPH DSM-IV BPND VBM SRTM TAC Fallypride ROI ICC Ventral striatum AST attention-deficit hyperactivity disorder ADHD Partial volume correction Positron emission tomography Dopamine Diagnostic and Statistical Manual of Mental Disorders, 4th edition Similarity index intraclass correlation coefficient Methylphenidate Visual analogue scales region of interest voxel-based morphometry ART Subjective alertness binding potential non-displaceable binding potential PVC Quantification

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Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest

Authors

Natalia del Campo, Roger J. Tait, Julio Acosta-Cabronero, Young T. Hong, David Izquierdo-Garcia, Rob Smith, Franklin I. Aigbirhio, Barbara J. Sahakian, Ulrich Müller, Trevor W. Robbins, Tim D. Fryer,