Article ID Journal Published Year Pages File Type
6034558 NeuroImage 2011 9 Pages PDF
Abstract
►Simultaneous NIRS and fMRI recording without hypercapnia. ►Quantification of both hemodynamics and metabolic parameters from SVD patients during a simple motor task. ►In SVD patients, we observed the followings: oxy-hemoglobin, total-hemoglobin, blood oxygenation level-dependent (BOLD) response, cerebral blood flow (CBF), and CMRO2 were decreased significantly in the primary motor and somatosensory cortices. ►Oxygen extraction fraction was increased. ►Flow-metabolism coupling ratio, n, which represents the neurovascular coupling showed a robust reduction.
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