Gray matter alterations related to P300 abnormalities in subjects at high risk for psychosis: Longitudinal MRI-EEG study

► P300 amplitude is lower in subjects at high risk for psychosis than in controls. ► High risk subjects show reduced frontal and temporo-parietal gray matter volume. ► P300 abnormalities in high risk subjects are related to gray matter alterations. ► In future it may be possible to use multimodal neuroimaging to predict psychosis.