Different left brain regions are essential for grasping a tool compared with its subsequent use

►A left brain network is responsible for planning tool use and preceding grasping. ►A behavioral and anatomical dissociation between grasping and tool use was found. ►Apraxia patients produce less errors during grasping than during the subsequent use. ►Lesions in the left SMG are prominent in most patients with impaired tool use ►Lesions in the left IFG are prominent in most patients with inappropriate grasping.