Abnormal brain activation during working memory in children with prenatal exposure to drugs of abuse: The effects of methamphetamine, alcohol, and polydrug exposure

►Prenatal methamphetamine exposure leads to altered brain activation during working memory. ►Prenatal methamphetamine exposure leads to altered activation in fronto-striatal circuits. ►Prenatal alcohol and methamphetamine may have distinct effects on brain structure and function. ►Prenatal methamphetamine exposure may lead to structural damage in fronto-striatal circuits. ►Damage to fronto-striatal circuits may lead to rewiring of cortico-striatal networks.