Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6035816 | NeuroImage | 2010 | 11 Pages |
Abstract
One of the two scanners showed better intra-site reproducibility, while the intra-site CV for both scanners was significantly better than inter-site CV. However, when using nonlinear coregistration of FA maps, the average inter-site CV was below 2%. There was a consistent inter-site bias, FA values on site 2 were 1.0-1.5% lower than on site 1. Correction for this bias with a global scaling factor reduced the inter-site CV to the range of intra-site CV. Our results are encouraging for multi-centre DTI studies in larger populations, but also illustrate the importance of the image processing pipeline for reproducibility.
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Authors
Christian Vollmar, Jonathan O'Muircheartaigh, Gareth J. Barker, Mark R. Symms, Pamela Thompson, Veena Kumari, John S. Duncan, Mark P. Richardson, Matthias J. Koepp,