Improved recovery of the hemodynamic response in diffuse optical imaging using short optode separations and state-space modeling

► Small optode separations measurements help remove systemic interference in NIRS data. ► Simultaneous filtering and estimation allows better recovery of the HRF. ► Dynamic filtering take into account the non-stationary behavior of the interference. ► Works well even if the baseline short-long correlation is as low as 0.1.