Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6036139 | NeuroImage | 2010 | 8 Pages |
Abstract
The older subjects exhibited significantly lower DMN activity in the posterior cingulate (PCC, t-test PÂ <Â .001) as well as a tendency to lower activity in all other DMN regions in comparison to the younger subjects. We found no significant effect of age on DMN inter-connectivity. Conclusion. Effects of normal aging such as loss of PCC co-activity could be detected by ICA, but not by signal time course correlation analyses of DMN inter-connectivity. This either indicates lower sensitivity of inter-connectivity measures to detect subtle DMN changes or indicate that ICA and time course analyses determine different properties of DMN co-activation. Our results, therefore, provide fundamental knowledge for a potential future use of functional MRI as biomarker for neurodegenerative dementias where diminished DMN activity needs to be reliably differentiated from that observed in health aging.
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Authors
W. Koch, S. Teipel, S. Mueller, K. Buerger, A.L.W. Bokde, H. Hampel, U. Coates, M. Reiser, T. Meindl,