Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6037277 | NeuroImage | 2009 | 6 Pages |
Abstract
Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in the left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity.
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Authors
Lars Nyberg, Micael Andersson, Lars Forsgren, Susanna Jakobsson-Mo, Anne Larsson, Petter Marklund, Lars-Göran Nilsson, Katrine Riklund, Lars Bäckman,