MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field

From such T1-weighted images, acquired within 12 min, high-resolution 3D T1 maps were routinely calculated at 7 T with sub-millimeter voxel resolution (0.65-0.85 mm isotropic). T1 maps were validated in phantom experiments. In humans, the T1 values obtained at 7 T were 1.15 ± 0.06 s for white matter (WM) and 1.92 ± 0.16 s for grey matter (GM), in good agreement with literature values obtained at lower spatial resolution. At 3 T, where whole-brain acquisitions with 1 mm isotropic voxels were acquired in 8 min, the T1 values obtained (0.81 ± 0.03 s for WM and 1.35 ± 0.05 for GM) were once again found to be in very good agreement with values in the literature.