Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6038111 | NeuroImage | 2009 | 7 Pages |
Abstract
There is strong evidence that dopamine (DA) is implicated in higher-order cognitive functioning, but it remains controversial whether D1 receptor binding can be modified by cognitive activity. We examined striatal D1 binding potential (BP) in 20 younger (22-30Â years) and 20 older (65-75Â years) persons who underwent two [11C] SCH 23390 PET measurements, one while resting and one while performing a cognitive task taxing inhibitory functioning. The younger persons showed significant task-related BP reductions in sensorimotor, limbic, and associative striatum during cognitive activity compared to rest. Older persons showed no reliable BP reductions in any striatal subregion. These findings demonstrate that D1 receptor binding can be modified by cognitive activity in younger persons, but also provide novel evidence for the notion that human aging is associated not only with lower DA receptor density but also with altered modifiability of the DA system.
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Authors
Sari Karlsson, Lars Nyberg, Per Karlsson, HÃ¥kan Fischer, Petra Thilers, Stuart MacDonald, Yvonne Brehmer, Anna Rieckmann, Christer Halldin, Lars Farde, Lars Bäckman,