Quantity without numbers and numbers without quantity in the parietal cortex

In this study we applied fMRI-guided TMS to the left and right IPS, while independently manipulating stimulus and task. Our results showed that IPS involvement in numerical cognition is neither stimulus-specific nor specific for conceptual tasks. Thus, quantity judgments with numerical and non-numerical stimuli were equally affected by IPS-TMS, as well as a number conceptual task not requiring quantity comparisons. However, IPS-TMS showed no impairment for perceptual decisions on numbers without any conceptual processing (i.e. colour judgment), nor for conceptual decisions that did not involve quantity or number stimuli (e.g. summer object: 'bikini' or 'coat'?). These results are consistent with proposals that the parietal areas are engaged in the conceptual representation of numbers but they challenge the most common view that number processing is so automatic that the simple presentation of numbers activates the IPS and a sense of magnitude. Rather, our results show that the IPS is only necessary when conceptual operations need to be explicitly oriented to numerical concepts.