Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6038917 | NeuroImage | 2008 | 8 Pages |
Abstract
There were no effects of genetic status on behavioural performance in the working memory tasks in the 429 subjects and in the fMRI task (n = 85). A linear effect of NRG1 SNP8NRG221533 carrier status on neuronal activation emerged in the fMRI experiment. Hyperactivation of the superior frontal gyrus (BA 10) was correlated with the number of risk alleles. The fMRI data suggest that performance measures between groups did not differ due to a compensational activation of BA 10 in risk-allele carriers. Our results are in line with functional imaging studies in patients with schizophrenia, which also showed a differential activation in lateral prefrontal areas.
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Authors
Axel Krug, Valentin Markov, Thomas Eggermann, Sören Krach, Klaus Zerres, Tony Stöcker, N. Jon Shah, Frank Schneider, Markus M. Nöthen, Jens Treutlein, Marcella Rietschel, Tilo Kircher,