Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6039218 | NeuroImage | 2009 | 9 Pages |
Abstract
Imposing focal decreases on cortical CBF in conjunction with global mean normalization gives rise to spurious relative CBF increases in all of the regions reported to be hyperactive in PD. Since no PET study has reported absolute increases of CBF or CMRglc in any subcortical region in PD, we conclude that the relative increases reported in some studies most likely arise from biased normalization to the global mean.
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Authors
Per Borghammer, Paul Cumming, Joel Aanerud, Albert Gjedde,