Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6039975 | NeuroImage | 2008 | 6 Pages |
Abstract
Arterial spin labeled (ASL) perfusion MRI provides a noninvasive approach for longitudinal imaging of regional brain function in infants. In the present study, continuous ASL (CASL) perfusion MRI was carried out in normally developing 7- and 13-month-old infants while asleep without sedation. The 13-month infant group showed an increase (PÂ <Â 0.05) of relative CBF in frontal regions as compared to the 7-month group using a region of interest based analysis. Using a machine-learning algorithm to automatically classify the relative CBF maps of the two infant groups, a significant (PÂ <Â 0.05, permutation testing) regional CBF increase was found in the hippocampi, anterior cingulate, amygdalae, occipital lobes, and auditory cortex in the 13-month-old infants. These results are consistent with current understanding of infant brain development and demonstrate the feasibility of using perfusion MRI to noninvasively monitor developing brain function.
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Cognitive Neuroscience
Authors
Ze Wang, MarÃa Fernández-Seara, David C. Alsop, Wen-Ching Liu, Judy F. Flax, April A. Benasich, John A. Detre,