| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 604035 | Food Hydrocolloids | 2013 | 7 Pages |
α-Lipoic acid loaded nanostructured lipid carriers (ALA-NLC) were developed by high pressure homogenization (HPH) technology. The effects of polymer-surfactant emulsifying agents on the formation and stability of ALA-NLC were characterized by dynamic light scattering (DLS), rheological analysis, wide angle X-ray diffraction (WAXD), and high efficiency liquid chromatography (HPLC). The particles size, viscoelastic property and stability of ALA-NLC samples were significantly influenced by polymer–surfactant emulsifying agents. Polymer is considered as a primary emulsifying agent in ALA-NLC. Surfactants, which have small and flexible hydrophilic head group, would have strong interaction with polymer, and form strong interfacial film, thus could improve the stability of ALA-NLC. These results will be productive for better understanding of the preparation and stability of NLC, and two formulations applied here may have some potential applications for α-lipoic acid dietary supplement or nutri-cosmetics.
Graphical abstractThe oscillation results of ASP, and its size and total load amount changes during 3 months of storage.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► We designed ALA-NLC, which can be used in food solution or nutri-cosmetics. ► Polymers were used as emulsifying agents for stable ALA-NLC formulations. ► The load amount maintained in the carriers was NLC > SLN > NE during 3 months.
