Spatio-temporal point-spread function of fMRI signal in human gray matter at 7 Tesla

Thus, the PSF of the hyper-oxygenated BOLD response in human gray matter is narrower than that reported at 1.5 T, where macro-vessels dominate the mapping signals. The initial phase of this response is more spatially specific than later phases. Data acquisition methods that suppress macro-vascular signals should increase the spatial specificity of BOLD fMRI. The choice of optimal stimulus duration represents a trade-off between the spatial specificity and the overhead associated with short stimulus duration.