| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6043813 | World Neurosurgery | 2016 | 15 Pages |
Abstract
Our study suggests that OGOMV could exert a neuroprotective effect by inhibiting the P13D/Akt protein, attenuating inflammation, and cleaved caspase-3- and -9a-related apoptosis. This study also lends credence to support the notion that the prevention of OGOMV could attenuate proinflammatory cytokine mRNA and late-onset caspases in tMCAO and merits further study.
Keywords
iNOSMotor deficit indexTumor necrotic factor-αBWILDSMDIIL-1βMCP-1RT-PCRGAPDHPBSPI3KIL-65-bromo-2′-deoxyuridineROStransient middle cerebral artery occlusioninterleukin-6Interleukin-1βBADBrdUinducible nitric oxide synthaseTNF-αphosphatidylinositol-3-kinaseLithium dodecyl sulfateCSFCerebrospinal fluidPhosphate-buffered salinereverse transcription polymerase chain reactionmonocyte chemoattractant protein-1protein kinase Bglyceraldehyde-3-phosphate dehydrogenaseReactive oxygen species
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Authors
Chih-Zen Chang, Shu-Chuan Wu,