| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6045632 | World Neurosurgery | 2014 | 15 Pages |
Abstract
Elucidating the role of mononuclear-derived cells associated with gliomas is crucial in designing novel immunotherapy strategies. Much progress is needed to characterize markers to identify cell subsets and their specific regulatory roles. Investigation of MDCB can be clinically relevant. Specific MDCB populations potentially can be used for glioma therapy as a target or as cell vehicles that might deliver cytotoxic substances or processes to the glioma microenvironment.
Keywords
PGE2TNFMMDCXCRM-CSFTregCCLHIFGM-CSFTGFGBMCpGAPCFGFMMPCOXGMDMCPROSSTATHuman leukocyte antigenantigen-presenting cellHLAcyclooxygenaseTeminterleukintransforming growth factortumor necrotic factorCNSRegulatory T cellDendritic cellDendritic cellscentral nervous systemHypoxia-inducible factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)fibroblast growth factormatrix metalloproteinasemacrophage colony-stimulating factorgranulocyte macrophage colony-stimulating factorMacrophagesSignal transducer and activator of transcriptionmajor histocompatibility complexMHCMonocytesMicrogliamonocyte chemotactic proteinProstaglandin E2Glioblastoma multiformeGlioblastomaReactive oxygen species
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Authors
Sergiy V. Kushchayev, Yevgeniya S. Kushchayeva, Philip C. Wiener, Adrienne C. Scheck, Behnam Badie, Mark C. Preul,