Leisure-time physical activity and psychotropic medication: A prospective cohort study

•Recommended physical activity was weakly associated with psychotropic medication.•Moderate and vigorous activities were equally associated with psychotropic medication.•Higher volume of physical activity showed further benefits for mental health.•The associations were similar for the two main groups of psychotropic medication.

BackgroundPhysical inactivity is a major public health problem associated with an increased risk of mental health problems. The aim of this study was to examine the associations of leisure-time physical activity with subsequent psychotropic medication among middle-aged people employed at baseline.MethodsQuestionnaire survey data collected in 2000-02 among 40-60-year-old employees of the City of Helsinki (N = 8960) were linked with register data on prescribed psychotropic medication (74% gave permission to linkage). The mean follow-up time was 4.2 years. The analysis included 5961 respondents (78% women). The participants were classified into four groups according to physical activity recommendations. Cox regression analysis was used to calculate hazard ratios (HR) for the first psychotropic medication purchase.ResultsLeisure-time physical activity was associated with decreased risk of any psychotropic medication. After adjusting for prior psychotropic medication conditioning exercisers (HR = 0.65, 95% CI, 0.53-0.80), the vigorously active (HR = 0.83, 95% CI, 0.71-0.98) and the moderately active (HR = 0.85, 95% CI, 0.74-0.97) all showed a reduced risk of medication compared with the inactive. The associations were similar for the two main groups of psychotropic medication: antidepressants as well as sedatives and sleep medication.ConclusionsLeisure-time physical activity is potentially important for preventing mental health problems among the middle-aged.