Insulin-like growth factor 1 promotes the proliferation and committed differentiation of human dental pulp stem cells through MAPK pathways

Article ID	Journal	Published Year	Pages	File Type
6050703	Archives of Oral Biology	2016	8 Pages	PDF

Abstract

IGF-1 can promote the proliferation and osteo/odontogenic differentiation of hDPSCs by activating MAPK pathways.

Keywords

IGF-1 TGFß FGFs IGFs DSPP Odontogenesis osterix hDPSCs OCN qRT-PCR ERK RUNX2 DSP GAPDH CPC PBS Jnk FBS 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide BMPs c-Jun N-terminal kinase MAPK MTT ALP Alkaline phosphatase Osteocalcin Osteogenesis Cetyl pyridinium chloride Osx transforming growth factors Proliferation Differentiation fetal bovine serum Human dental pulp stem cells Dental pulp stem cells dentin sialophosphoprotein Dentin sialoprotein insulin-like growth factors Fibroblast Growth Factors insulin-like growth factor 1 platelet-derived growth factors Phosphate buffered saline quantitative reverse transcription polymerase chain reaction bone morphogenetic proteins extracellular regulated protein kinases mitogen-activated protein kinase optical density glyceraldehyde-3-phosphate dehydrogenase

Related Topics

Health Sciences Medicine and Dentistry Dentistry, Oral Surgery and Medicine

Insulin-like growth factor 1 promotes the proliferation and committed differentiation of human dental pulp stem cells through MAPK pathways

Authors

Lv Taohong, Wu Yongzheng, Mu Chao, Liu Genxia, Yan Ming, Xu Xiangqin, Wu Huayin, Du Jinyin, Yu (Professor, Vice Director), Mu (Lecturer),