Influence of cigarette smoking on synthesis of eicosanoids, isoprostanes and lipoxygenase metabolites in apical periodontitis

Our data demonstrate that in smokers with granuloma due to AP products of lipid peroxidation as 8-iso-PGF2α and products of the LOX-pathway are increased at the expense of cyclooxygenase products. The size of granuloma did not influence the amount of synthesized eicosanoids, IPs or LOX-metabolites out of 14C-AA whereas cigarette smoking was a significantly influencing and modifiable risk factor.