Dental pulp and gingivomucosa in rats are innervated by two morphologically and neurochemically different populations of nociceptors

Dental pulp and gingivomucosa are richly innervated by nociceptive TrkA-expressing neurons. However, while great majority of pulpal neurons are larger NGF-dependent A-fibre nociceptors without affinity to bind IB4, almost half of the gingival neurons are smaller IB4 binding C-fibre nociceptors. The difference in phenotype of sensory neurons might partially explain the different sensitivity of both tissues during normal and pathological conditions.