Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6052024 | Archives of Oral Biology | 2012 | 8 Pages |
Abstract
The regulatory effect of rhBMP-2 on angiogenesis and inflammation is mediated through a ROS-dependent mechanism, which involves upregulation of crucial angiogenic and inflammatory mediators such as VEGF and IL6. These findings highlight the need for future studies to identify new therapeutic targets downstream from rhBMP-2 to potentiate its beneficial effect or limit its complications such as seroma formation.
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Authors
Sara Akeel, Ahmed El-awady, Khaled Hussein, Mona El-Refaey, Mohammed Elsalanty, Mohamed Sharawy, Mohamed Al-Shabrawey,