Reactive Oxygen Species Removal Activity of Davallialactone Reduces Lipopolysaccharide-induced Pulpal Inflammation through Inhibition of the Extracellular Signal-regulated kinase 1/2 and Nuclear Factor kappa B Pathway

Davallialactone has antioxidant activity and anti-inflammatory effects in LPS-induced human dental pulp cells through the suppression of ERK1/2 activation followed by blockage of NF-κB translocation from cytosol into nuclear. Therefore, the good anti-inflammatory capacity of davallialactone might be used for oral diseases such as pulpitis and periodontitis.