Chemoradiation of locally advanced squamous cell carcinoma of the head-and-neck (LASCCHN): Is 20Â mg/m2 cisplatin on five days every four weeks an alternative to 100Â mg/m2 cisplatin every three weeks?

20 mg/m2 cisplatin on five days every four weeks was associated with fewer adverse events than 100 mg/m2 cisplatin every three weeks. 100 mg/m2 cisplatin was not significantly superior to 20 mg/m2 cisplatin regarding LRC, MFS and OS. Given the limitations of a retrospective study, 20 mg/m2 cisplatin appeared preferable. The results should be confirmed in a randomized trial.