Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6054933 | Oral Oncology | 2015 | 7 Pages |
Abstract
We therefore show that TGF-α can have both growth-stimulating and growth-inhibiting effects in the same cell line and that EGFR-targeting drugs can be similarly double-edged. The implication for such drugs is that the micro-environment within a tumour, and possibly within portions of a tumour, may influence the growth-inhibiting effect of the drug. There may also be important implications for our understanding of EGFR signalling and its influence on growth and development.
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Authors
Lars Ekblad, Charlotte Welinder, Elisabeth Kjellén, Eva Brun, Johan Wennerberg,