Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6057040 | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | 2013 | 8 Pages |
ObjectiveDefinitive therapy is not defined for the management of oral submucous fibrosis (OSMF). This study evaluated the efficacy of aloe vera gel as an adjuvant treatment of OSMF.Study DesignA double-blind, placebo-controlled, parallel-group randomized controlled trial was conducted on 60 subjects with OSMF divided into medicinal treatment (submucosal injection of hyaluronidase and dexamethasone, n = 30) and surgical treatment (n = 30) categories. Each category was randomly divided into groups A (with aloe vera, n = 15 per category) and B (without aloe vera, n = 15 per category). Follow-up assessment for various symptoms was performed, and results were analyzed using paired and unpaired Student t tests.ResultsThe group receiving aloe vera had a significant improvement in most symptoms of OSMF (P < .01) compared with the non-aloe vera group, in both the medicinal and surgical categories.ConclusionsAloe vera gel was effective as an adjuvant in treatment of OSMF.