| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6058172 | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | 2013 | 8 Pages |
Abstract
IHC revealed 79.6% staining of SIRT1 in HNSCC, while almost all normal tissues showed positive staining. SIRT1 expression predominated in cases involving patients aged >65Â years, lymph node negative, and early clinical stage cases. It was positively and statistically correlated with expression of acetylated histone H3K9 and H4K16, but not with p53. Multivariate analyses revealed that expression of SIRT1 was an independent and good indicator of prognosis.
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Authors
Akira DDS, Xiaohan MD, PhD, Akira MD, PhD, Keiji PhD, Yoichi MD, PhD, Hauchaun PhD, Yohei MD, PhD, Ichiro MD, PhD, Yasuo MD, PhD,