Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6058784 | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | 2012 | 4 Pages |
Abstract
Diffuse sclerosing osteomyelitis of the mandible (DSOM) is an uncommon chronic inflammatory disease of bone that is refractory to conventional treatments, such as antibiotics, nonsteroidal anti-inflammatory drugs, and decortication. We report a case of chronic DSOM of 15 years' duration in a 61-year-old woman that was successfully treated with a single infusion of pamidronate. Persistent, intractable pain resolved 3 days after infusion. Intense accumulation on 99mTc scintigraphy decreased 2 months after infusion, and almost disappeared after 3 years. Panoramic radiography demonstrated a clear decrease in pathologic changes, close to that of normal bone architecture, which has not been reported in DSOM treated with bisphosphonates.
Related Topics
Health Sciences
Medicine and Dentistry
Dentistry, Oral Surgery and Medicine
Authors
Masahiro DDS, PhD, Kazuma DDS, PhD, Kazuki DDS, PhD, Kuniyasu DDS, PhD, Hiromitsu DDS, PhD,