Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6059112 | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | 2012 | 6 Pages |
Abstract
Ghost cell odontogenic carcinoma (GCOC) is a rare malignant variant of odontogenic tumor with ghost cells; only 29 cases are documented. Our patient was a 68-year-old man with a painless, well-defined, radiolucent swelling of the mandibular gingiva in the right incisor-to-molar region. It was diagnosed as a benign calcifying cystic odontogenic tumor (CCOT) on fenestration biopsy. Eighteen years later, he returned with swelling in the same area. The lesion was excised, diagnosed as GCOC, and considered a secondary malignant manifestation of the benign CCOT. No adjuvant chemotherapy or radiotherapy was administered, and his postoperative course was uneventful for 48 months, with no recurrence or distant metastasis. Among the 30 reported cases of GCOC, the mean age at diagnosis was 40.3 years, 22 (73%) involved the maxilla. Twelve (40%) were secondary malignant manifestations of benign CCOTs or dentinogenic ghost cell tumors. Five patients died of recurrence or distant metastasis.
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Authors
Takaroni DDS, Yasumitsu DDS, PhD, Takanori DDS, PhD, Hideyuki DDS, PhD, Ritsuo DDS, PhD, Takafumi DDS, PhD, Jun MD, PhD, Takashi DDS, PhD,