| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6059944 | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology | 2011 | 9 Pages |
ObjectiveThe objective was to study the radiological and histologic changes in the mandibular cortices of ovariectomized monkeys.Study designTwelve female, adult, Cynomolgus monkeys (Macaca fascicularis) were used. Under anesthesia, 1 group was bilaterally ovariectomized (OVX), and the other (control group) underwent sham surgery. Seventy-six weeks after surgery, the monkeys were humanely killed, their mandibles were excised, and their mandibular inferior cortices (MIC) and adjacent cortices were examined histologically and with panoramic radiographs and micro computed tomography.ResultsStriped shadows were seen on the endosteal side of the OVX cortices on panoramic radiographs. Histologic observation revealed many enlarged pores with eroded surfaces and calcein labeling (indicating osteon remodeling) in the OVX cortices.ConclusionsIn the MIC and adjacent cortices of OVX monkeys, enlarged Haversian canals were seen and there were indications of a high rate of bone turnover. The enlarged Haversian canals resulted in striped shadows and unclear endosteal margins on radiographic images.
